Physical activity and COVID-19: an observational and Mendelian randomisation study《Journal of Global Health》
Xiaomeng Zhang, Xue Li, Ziwen Sun, Yazhoou He, Wei Xu, Harry Campbell, Malcolm G Dunlop, Maria Timofeeva*, Evropi Theodoratou*
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作者:ZHANG Xiaomeng, LI Xue, SUN Ziwen, HE Yazhoou, XU Wei, CAMPBELL Harry, DUNLOP Malcolm G, TIMOFEEVA Maria, THEODORATOU Evropi
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发布时间: 2020-12-01
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Abstract
Background Physical activity (PA) is known
to be a protective lifestyle factor against several
non-communicable diseases while its impact
on infectious diseases, including Coronavirus
Disease 2019 (COVID-19) is not as clear.
Methods We performed univariate and multivariate logistic regression to identify associations between both objectively and
subjectively measured PA collected prospectively and COVID-19 related outcomes (overall COVID-19, inpatient COVID-19, outpatient COVID-19, and COVID-19 death) in the
UK Biobank cohort. Subsequently, we tested
causality by using Mendelian randomisation
(MR) analyses.
Results In the multivariable model, the increased acceleration vector magnitude PA
(AMPA) is associated with a decreased probability of overall and outpatient COVID-19 with
an odds ratio (OR) and 95% confidence interval (CI) of 0.80 (0.69, 0.93) and 0.74 (0.58,
0.95), respectively. No association is found between self-reported moderate-to-vigorous PA
(MVPA) and COVID-19 related outcomes. No
association is found by MR analyses.
Conclusions Our results indicate a protective effect of objectively measured PA and
COVID-19 outcomes (outpatient COVID-19
and overall COVID-19) independent of age,
sex, measures of obesity, and smoking status.
Although the MR analyses do not support a
causal association, that may be due to limited
power. We conclude that policies to encourage and facilitate exercise at a population level
during the pandemic should be considered.
DOI: 10.7189/jogh.10.020514